No Easy Way Out (Or in)

No Easy Way Out (Or in)

In retrospect, when Jardetzky (1966) published a " simple allosteric model for membrane pumps, " he initiated a conceptual movement away from the (then still) prevailing anthropomorphic view of transporters and pumps as " carriers " in the literal sense, membrane-bound entities that somehow made their way across the membrane, loaded with cargo. The idea of an " alternating access " model (as it...

No Easy Way Out ( or In )

Complex Linguistic Annotation - No Easy Way Out! A Case from Bangla and Hindi POS Labeling Tasks

Alternative paths to linguistic annotation, such as those utilizing games or exploiting the web users, are becoming popular in recent times owing to their very high benefit-to-cost ratios. In this paper, however, we report a case study on POS annotation for Bangla and Hindi, where we observe that reliable linguistic annotation requires not only expert annotators, but also a great deal of superv...

Chlamydia pneumoniae and atherosclerosis: no way-out or long way? What about renal failure patients?

Recently, Chlamydia pneumoniae is the microorganism frequently implicated in the infection-based inflammatory atherogenous hypothesis. Although in vitro experimental data and initial sero-epidemiologic, pathology-based studies and antibiotic trials supported this interesting hypothesis, later data are conflicting. Some confounding factors are the causes of uncertainty; lacking of standard metho...

The hepatopulmonary syndrome: NO way out?

"How diseases of the liver affect lung function?" is one of those puzzling questions that can turn obsessive for those who want to understand how two seemingly distinctive organs can interact and eventually lead to severe disorders [1, 2]. The most common respiratory consequence of liver disease is hypoxaemia, which is often mild to moderate [3]. Seldom severe hypoxaemia occurs when the arteria...